Pengaruh Pemberian Ekstrak Bawang Dayak terhadap Delayed Onset Muscle Soreness (DOMS) Ditinjau dari Kadar TNF-α The Effect of Dayak Onion Extract on Delayed Onset Muscle Soreness (DOMS) in Terms of TNF-α Levels

Abstract

Excessive physical activity can cause Delayed Onset Muscle Soreness (DOMS), which is associated with increased oxidative stress and inflammation. One of the key inflammatory markers is TNF-α (Tumor Necrosis Factor Alpha). Dayak onion contains active compounds such as flavonoids, saponins, and tannins, which have antioxidant and anti-inflammatory properties. This study aimed to analyze the effect of Dayak onion extract on TNF-α levels in a rat model of DOMS induced by the Forced Swimming Test (FST). This study employed a Randomized Pre and Post Test Control Group Design using male Sprague Dawley rats aged 2 months (weighing 150–200 g). The rats were divided into five groups: K- (no Dayak onion extract, subjected to FST), K+ (received xanthine and FST), and three treatment groups receiving Dayak onion extract at doses of 50 mg/200 g BW (P1), 100 mg/200 g BW (P2), and 200 mg/200 g BW (P3) for 21 days, followed by an FST to evaluate its effect on TNF-α levels. The administration of Dayak onion extract for 21 days significantly reduced TNF-α levels. The P3 group (200 mg/200 g BW) showed the highest reduction (91.36% compared to K-) and was not significantly different from the K+ group. The most effective dose for reducing TNF-α levels associated with DOMS was 200 mg/200 g BW/day (P3).